Simon has produced four major books: For Most Of It I Have No Words (1998) about the landscapes of genocide, Afghanistan: Chronotopia (2002), 'Bleed' (2005) about the war in Bosnia, and Burke + Norfolk (2011), a re-discovery and re-photographing of John Burke's nineteenth century pictures from Afghanistan. This work was exhibited at Tate Modern in London in one of the gallery’s rare solo photographic shows.
Simon’s work has been widely recognized. He won the 2002 European Publishing Award, the Foreign Press Club of America Award in 2003, The 2004 Infinity Award: Photojournalism from The International Center of Photography, the 2005 Le Prix Dialogue at Les Rencontres d'Arles, a Sony World Photography award in 2012, World Press Photo awards in 2001 and 2012, and the fourth Prix Pictet Commission in 2012.